Study: Identified “Thin Gene” Helps Prevent Weight Gain

New research published in the journal Cell concerns the discovered “thin gene,” a gene that helps some individuals stay thin while others must diligently diet and exercise. Take a moment to learn about this study as part of your continuing weight loss education with Phentermine 37.5mg.

The Study

Researchers worked with 47,000 participants in Estonia to identify a gene connected to thin, trim physiques. The gene is believed to prevent excessive weight gain while also helping regulate energy output.

“We all know these people: it’s around one percent of the population,” says senior author Josef Penninger, director of the Life Sciences Institute and professor of the medical genetics department at the University of British Columbia. “They can eat whatever they want and be metabolically healthy. They eat a lot, they don’t do squats all the time, but they just don’t gain weight.

“Everybody studies obesity and the genetics of obesity,” he says. “We thought, ‘Let’s just turn it around and start a new research field.’ Let’s study thinness.”

Gene-Targeted Therapeutics

The research team notes that targeting this gene, known as the ALK gene, can help scientists combat the obesity epidemic.

“If you think about it, it’s realistic that we could shut down ALK and reduce ALK function to see if we did stay skinny,” says Penninger. “ALK inhibitors are used in cancer treatments already. It’s targetable. We could possibly inhibit ALK, and we actually will try to do this in the future.”

Studies with the gene will subsequently continue.

“You learn a lot from biobanks,” says Penninger. “But, like everything, it’s not the ultimate answer to life, but they’re the starting points and very good points for confirmation, very important links and associations to human health.”

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