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Gut bacteria & the body’s circadian clock: how they work together to expand waistlines

A new study on gut bacteria and the body’s circadian clock has found the two work together to make you gain weight. The study was conducted by the UT Southwestern Medical Center and published in the journal Science. Take a moment to learn about this study as part of your new Phentermine 37.5mg weight loss education:

Predisposition To Weight Gain?

“These findings indicate a mechanism by which the intestinal microbiota regulate body composition and establish the circadian transcription factor NFIL3 as the essential molecular link among the microbiota, the circadian clock, and host metabolism,” said Dr. Lora Hooper, Chair of Immunology at UT Southwestern Medical Center and lead author of the study.

“The human gut is teeming with trillions of bacteria that help us digest our food, protect us from infection, and produce certain vitamins. There is accumulating evidence that certain bacteria that live in our gut might predispose us to gain weight, especially when we consume a high-fat, high-sugar ‘Western-style’ diet,” added fellow lead author and UT Southwestern Medical Center graduate student Yuhao Wang.

Regulation Of NFIL3

The gut’s circadian clock helps regulate NFIL3 and therefore the lipid metabolic machinery managed by NFIL3 in the body’s intestinal lining. Circadian clocks sense day and night, and associate them with feeding times. Yet these clocks also capture light cues from the body’s visual and nervous systems to regulate gene expression.

“So what you have is a really fascinating system where two signals from the environment come in — the microbiome and the day-night changes in light — and converge on the gut lining to regulate how much lipid you take up from your diet and store as fat,” said Dr. Hooper.

“Our work provides a deeper understanding of how the gut microbiota interacts with the circadian clock, and how this interaction impacts metabolism,” she continued. “It could also help to explain why people who work the night shift or travel abroad frequently — which disrupts their circadian clocks — have higher rates of metabolic diseases such as obesity, diabetes, and cardiovascular disease.”

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