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About Phentermine
What are the adverse effects?
Generally, phentermine appears to be relatively well tolerated. Adverse effects by incidence:
Uncommon (less than 1 percent incidence) adverse effects include:
| Xerostomia (dry mouth) | Tachycardia | Urinary frequency |
| Restlessness | Hypertension | Facial oedema |
| Nervousness | Diarrhea | Unpleasant taste |
| Euphoria | Vomiting | Urticaria |
| Agitation | Headache | Impotence |
| Arrhythima | Rash | Change in libido |
Uncommon (less than 1 percent incidence) adverse effects include:
| Valvular heart disease (in combination with dexfenfluramine and fenfluramine; causal relationship unc |
| Primary pulmonary hypertension |
| Increased seizure activity in people with epilepsy |
| Psychosis |
| Withdrawal symptoms on stopping |
| Dysphoria |
| Ischaemic events |
Cautions
Phentermine use is contraindicated in those who are:
| Known hypersensitivity or idiosyncratic reaction to sympathomimetic amines |
| Taking amphetamine (i.e., Adderall, Dexedrine, Vyvanse), dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine) in the last 14 days |
| Hyperthyroidism |
| Glaucoma |
| Peptic ulcer |
| Prostatic hypertrophy |
| Epilepsy |
| Cotreatment with drugs that increase blood pressure |
| Contraindicated in cardiac disease (e.g. advanced arteriosclerosis, pulmonary hypertension, uncontrolled hypertension, arrhythmias) and cerebrovascular disease (stroke) Pregnant, planning to become pregnant, or are breast-feeding |
| Those receiving serotonergic medications such as the selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitor, tricyclic antidepressant, due to the potential for serotonin syndrome to be precipitated by the cotreatment. |
Medicines which may interact with phentermine, such as dexfenfluramine, fenfluramine, furazolidone, or MAOIs (e.g., phenelzine) are contraindicated because of the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased. Guanadrel (Hylorel) or guanethidine (Ismelin) effectiveness may be decreased by phentermine. Antacids may decrease the excretion of phentermine.
Carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, methazolamide) may decrease the excretion of phentermine.
Is Phentermine Legal?
Phentermine has been F.D.A. approved as a medication well tolerated for decades. Phentermine is classed as drug, it is legal but a controlled substance and is subject to the laws set out in individual countries or at state level.
How does it work?
The substance main mechanic of action affects the hypothalamus portion of the brain to provoke the adrenal glands to release norepinephrine a neurotransmitter or chemical transmitter that responds to a fight-or-flight response that in turn can help to reduce the want or need for food.
Phentermine also has a secondary effect by causing the secretion of epinephrine or adrenaline, causing fat cells in the body to break down stored fat. It main target is reduce hunger and increase satiety. It can also release serotonin and dopamine (natural hormones within body), but to a reduced extent than that of norepinephrine.
Is it suitable for anyone?
Most countries where it is provided, prescribe only for patients 16 and over.Pregnant or breastfeeding mother are advised to avoid.
Not recommended for anyone who suffers from pre-existing medical conditions, such as heart disease, thyroid problems, glaucoma, has mental issues or a history of drug abuse.