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Study: Brain Insulin Sensitivity Influences Fat Distribution & Body Weight

According to a new study, how and where fat gets deposited in the body depends not only on lifestyle habits, but the brain’s sensitivity to insulin. Researchers at the German Center for Diabetes Research (DZD), Helmholtz Zentrum München and Tübingen University Hospital published a study in Nature Communications discussing this sensitivity and how it may be one of the reasons for the obesity epidemic. Learn about this study, which was published in the journal Nature Communications, as part of your commitment to fast weight loss with Phentermine 37.5mg

Insulin Sensitivity & Fat Deposits

The degree of brain insulin sensitivity influences where fat gets stored on the body. If the brain responds “sensitively” to the hormone, it becomes easier to lose weight, including visceral fat around the abdomen. Conversely, if the brain barely responds to insulin or not at all, weight loss becomes more challenging and visceral fat can increase over time. Visceral fat is particularly harmful because it releases neurotransmitters that influence insulin secretion and can affect blood pressure while increasing inflammation. The risk of certain cancers, diabetes, and cardiovascular disease also heightens. 

High Sensitivity & Reduced Visceral Fat

Over the course of a nine-year study, researchers found insulin activity in the dictates fat distribution and body weight. 

"Subjects with high insulin sensitivity in the brain benefited from the lifestyle intervention with a pronounced reduction in weight and visceral fat. Even after the lifestyle intervention had ended, they only regained a small amount of fat during the nine-year follow-up," said lead study author Professor Martin Heni from Tübingen University Hospital. 

Additionally, those with brain insulin resistance saw a slight weight loss during the initial nine months of the researchers’ program. 

"Afterwards, their body weight and visceral fat increased again during the following months of lifestyle intervention," added first author Dr. Stephanie Kullmann from the IDM.

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About the Author

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